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OT: Health and Nutrition

zeke said:
not miserable. just emotionless. no ups, no downs.

no joy. no pain. no art. just math.
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Yeah that hasn't been observed at all in any large clinical studies, sounds like a dosage issue to me. Plenty of reports of mental health and happiness improving, rarely the opposite. At the right doese it's usually the food noise that regulates and flattens, not the other stuff.
 
axlsalinger said:
My knowledge is limited on the subject, and the experts don't even know exactly what's going on, but on a basic level, Ozempic stimulates a hormone called glucagon-like peptide-1 (ie. GLP-1) that already occurs naturally in the body to regulate blood sugar and hunger signals. Turns out this ends up helping regulate dopamine as well, which is clear in the data, but we don't know exactly how. There's definitely the possibility there will be negative long-term effects, but we don't know for sure, and they have been working on these drugs and testing since the 90s. So if it were really dangerous we'd likely have some idea by now.

It does seem pretty clear that the benefits from weight loss will almost certainly outweigh any negative aspects. And it helps regulate dopamine, not destroy it. And from what I know, these effects wear off when people stop taking the drug. People should not stay on these drugs indefinitely.
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It seems quite obvious now that big sugar is trying to smear the perception of the drug....
 
axlsalinger said:
From Gemini:

While there is no specific clinical evidence that GLP-1 drugs can cure an "irrational hatred" of potatoes, these medications significantly alter how the brain and body process food-related cues, which can lead to shifts in food preferences and aversions.

Effects on Food Perception and Aversion
  • Sensory Recalibration: GLP-1 drugs can cause a "deeper recalibration" of how flavor is registered, sometimes leading to a complete loss of interest in once-beloved foods or, conversely, making previously unappealing healthy foods taste better.
  • Quieting "Food Noise": These medications reduce intrusive thoughts about food by influencing brain circuits related to appetite, reward, and motivation.
  • Taste Changes: Users frequently report altered taste sensations (dysgeusia), such as food tasting more metallic, too intense (especially sweet or salty), or simply "odd".
  • Reduced Reward Response: By dampening the brain's reward system, GLP-1s can make the anticipation of eating certain foods less intense.

Potential Impact on Food Aversions
  • Shifting Preferences: Many users report major changes in preferences, often moving away from fatty, fried, or ultra-processed foods toward "savory umami" or simpler flavors.
  • Gender Differences: Some research suggests women may be more likely than men to experience a change in taste preferences while on these drugs.
  • Psychological Limits: While these drugs impact the physiological and neurological drive to eat, they do not typically address deep-seated psychological drivers of eating behaviors or specific trauma-related food phobias.
If your "hatred" is purely sensory—based on the taste or texture of potatoes—the medication's ability to rewire your palate might make them more tolerable. However, if the aversion is deeply psychological or rooted in a specific phobia, the drug's effect on appetite may not be enough to overcome it without additional behavioral therapy.
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Preston said:
Note to Zeke: if these impacts sound bad to you, please be reassured that this drug is not mandatory. You can choose to not take anything and raw dog life. #freedum
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Life is more fun while hammered. Shitty side effects though.
 
zeke said:
are these large clinical studies run by pharma companies
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Yes usually, just like the vaccine studies, but they are double blinded and placebo controlled and audited/reviewed by independent bodies. Now do we believe those or the guesses based on internet vibes that everyone who takes it becomes a zombie?
 
What would happen if I injected potato juice int my veins

Injecting potato juice into your veins would be extremely dangerous and could quickly become life-threatening. Veins are only meant to carry sterile, properly formulated medical fluids. Raw potato juice is none of those things. Several serious problems could happen:

1. Immediate infection 🦠​

Potato juice contains bacteria, fungi, and environmental microbes from the potato and whatever prepared it. Injecting that directly into the bloodstream could cause:
  • Sepsis (a body-wide infection)
  • High fever, shock, organ failure
Even a small amount of contaminated fluid can cause this.

2. Blood vessel blockage 🫀​

Potato juice contains:
  • Starch granules
  • Plant fibers
  • Cell fragments
These particles could clog small blood vessels (similar to an embolism). If they reach the lungs, brain, or heart, they could cause:
  • Pulmonary embolism–like effects
  • Stroke
  • Tissue death

3. Severe immune reaction ⚠️​

Your immune system would treat the plant material as foreign. That could trigger:
  • Massive inflammation
  • Allergic or anaphylactic reactions
  • Blood clotting abnormalities

4. Chemical toxicity 🧪​

Potatoes contain compounds such as glycoalkaloids (like solanine), which are meant to defend the plant from pests. Injecting these directly into blood could cause:
  • Nerve symptoms
  • Heart rhythm disturbances
  • Organ damage

5. Blood chemistry disruption​

Intravenous fluids must have very precise salt balance and pH. Potato juice does not. Injecting it could cause:
  • Red blood cell damage (hemolysis)
  • Dangerous electrolyte shifts
✅ Bottom line: Injecting potato juice would almost certainly lead to severe infection, clots, or organ failure, and could easily be fatal.
Potatoes are great eaten, fried, roasted, mashed, or even fermented—but the bloodstream is one place they absolutely should never go. 🥔

What if it was a sterile potato?

Even if the potato itself were sterile, injecting potato juice into a vein would still be very dangerous.
The main problem isn’t just germs — it’s that plant juice is chemically and physically incompatible with blood.

1. Starch particles would clog blood vessels 🥔​

Potato juice contains large starch granules and plant cell debris. These particles are far bigger than what can safely circulate in blood. If injected they could:
  • Block tiny capillaries
  • Lodge in the lungs (similar to a pulmonary embolism)
  • Potentially reach the brain and cause stroke-like effects
Your circulatory system expects clear dissolved molecules, not suspended plant particles.

2. Red blood cells could rupture​

Human blood is very sensitive to osmolarity (salt/sugar balance). IV fluids are carefully made to match blood. Potato juice would almost certainly be hypotonic, meaning water would rush into red blood cells and cause hemolysis (cells bursting).
That can lead to:
  • Kidney damage
  • Shock
  • Dangerous electrolyte changes

3. Immune and clotting reactions​

Even sterile plant molecules would be treated as foreign biological material. That could trigger:
  • Severe inflammatory reactions
  • Complement activation (immune system cascade)
  • Abnormal clotting

4. Natural potato chemicals​

Potatoes naturally contain glycoalkaloids such as Solanine and Chaconine. These are mild toxins even when eaten in large amounts. Injected directly into blood, the body has no digestive buffering, so the toxic effects could be stronger.
✅ In short:
Even perfectly sterile potato juice would likely cause embolism, red-cell destruction, severe inflammation, and possible organ failure if injected intravenously.
Your bloodstream is designed for very specific sterile solutions (saline, glucose solutions, medications). Pretty much anything resembling “food juice” would be medically catastrophic if injected. 🩸🥔

What’s the difference between potato juice and vaccines?

The key difference is that vaccines are carefully engineered sterile medical products, while potato juice is just plant fluid with none of the properties required to be safely injected into the body.
Here are the main differences:

1. Purity and sterility 🧪​

Vaccines are produced under strict pharmaceutical manufacturing standards (called GMP). They are:
  • Sterile
  • Purified
  • Filtered to remove particles
  • Tested batch-by-batch for contamination
Potato juice—even from a “clean” potato—contains:
  • Plant cells
  • Starch granules
  • Proteins
  • Natural toxins
  • Environmental microbes
Those particles alone would make it unsafe to inject.

2. Particle size and formulation​

Injectable medicines must be clear solutions or extremely well-controlled suspensions. Particles have to be tiny and uniform so they can circulate safely.
Potato juice contains large starch granules and cell fragments, which could block tiny blood vessels.

3. Known ingredients vs unknown mix​

Vaccines contain known, measured components, such as:
  • A small amount of antigen (a piece of a virus or bacterium)
  • Stabilizers
  • Sometimes adjuvants that help the immune system respond
For example:
  • Pfizer–BioNTech COVID‑19 vaccine contains mRNA packaged in lipid nanoparticles.
  • MMR vaccine contains weakened forms of those viruses.
Every ingredient and dose is precisely controlled and tested.
Potato juice is chemically complex and not standardized—every potato would produce a different mixture.

4. Osmolarity and compatibility with blood​

Injected solutions must match the body’s salt balance and pH so they don’t damage cells. Medical fluids are formulated to be close to blood chemistry.
Potato juice would likely have the wrong osmolarity and could damage red blood cells or tissues.

5. Purpose​

Vaccines are designed to train the immune system safely by presenting a specific antigen. They trigger a controlled immune response that leads to immune memory.
Potato juice has no targeted immune function. If injected, it would just look like foreign debris and toxins to the body.
Simple analogy:
A vaccine is like a precision-engineered training signal for the immune system.
Potato juice would be more like injecting plant soup into the bloodstream, which the body isn’t built to handle. 🥔🩸

Again - we’re talking about sterile potatoes.

Even if you somehow had a perfectly sterile potato and extracted juice under sterile conditions, the fundamental problems remain. Sterility removes microbes, but it doesn’t make the fluid compatible with human blood.

1. Suspended particles​

Potato juice contains starch granules and plant cell fragments. These are solid particles typically tens of microns across, while the smallest blood vessels (capillaries) are only about 5–10 microns wide. Injecting that suspension could cause micro-emboli—tiny blockages in capillaries, especially in the lungs.

2. Osmolarity and pH mismatch​

Intravenous fluids must be close to the body’s osmolarity (~300 mOsm/L) and physiological pH. Potato juice would not be formulated to match that. If the solution is too hypotonic, red blood cells can swell and rupture (hemolysis). If it’s off in other directions, it can damage tissues and disrupt electrolytes.

3. Biochemical incompatibility​

Even sterile plant molecules are foreign biological material to the bloodstream. Proteins, enzymes, and other compounds from potatoes could trigger:
  • complement activation (a strong innate immune response)
  • inflammation
  • abnormal clotting

4. Naturally occurring potato compounds​

Potatoes contain glycoalkaloids such as Solanine and Chaconine. When eaten, the digestive system limits and processes these; injected directly into blood, the body has no such buffer.

5. Lack of medical formulation​

Injectable products (saline, medications, vaccines) are not just sterile—they are:
  • purified
  • filtered to remove particles
  • chemically buffered
  • tested for compatibility with blood and tissues
Sterile potato juice would still be an unfiltered plant extract, not a medically formulated injectable solution.
Bottom line: Sterility alone doesn’t make something safe to inject. Even sterile potato juice would likely cause vascular blockage, red-cell damage, and severe inflammatory reactions if introduced directly into the bloodstream.
 
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