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OT: Health and Nutrition

MindzEye said:
I'm saying that the way dopamine works isn't just an on/off switch on this one type of receptor and the mechanism of these drugs doesn't just turn off the receptors. It's complicated, and the end result of using the drug is that you're no long hyper stimulated by your previous dopamine addictions while on it.
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so it removes some, not all, of the dopamine rewards.

just the right amount.
 
zeke said:
so it removes some, not all, of the dopamine rewards.

just the right amount.
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iu
 
zeke said:
so it removes some, not all, of the dopamine rewards.

just the right amount.
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Well that's why you need to find the right dosage. It's meant to regulate and restore a healthy baseline for people who don't have a healthy baseline and whose signals are off.

Tylenol is the same. If I have a bad headache I take an extra strength! Or T3s if I get cock surgery! This is how medication works!
 
Preston said:
Well that's why you need to find the right dosage. It's meant to regulate and restore a healthy baseline for people who don't have a healthy baseline and whose signals are off.

Tylenol is the same. If I have a bad headache I take an extra strength! Or T3s if I get cock surgery! This is how medication works!
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i mean but more and more dopamine removal should mean more and more weight loss.
 
zeke said:
i mean but more and more dopamine removal should mean more and more weight loss.
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Why? Dopamine isn't the only hormone involved in hunger, satiety, etc. It's not even the dominant one. It's just the one that makes us make bad decisions more often.

Like, GLP-1 could have saved you from banging that...lovely lady, I'm sure....in the bathroom of a fast food restaurant back in the day. But it also would have probably stopped you from weighing your nuts and talking about it on the internet, so you know, not all good news.
 
zeke said:
i mean but more and more dopamine removal should mean more and more weight loss.
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If you take 20 tylenol for a mild headache, you don't get extra healed! It's the same with dopamine, you don't want more and more removal. You want the exact amount that helps support your disease/addiciton/mental illness. You need just enough reformatting to bring the food noise down to a level where you can actually make a choice about what to eat.

The starting dose is 2.5mg, it's known as the therapeutic dose because it generally doesn't work for many - roughly 10% respond to it; side effects are low and effectiveness is low. Those super responders that shed weight on that dose will often stay at 2.5mg. Others have to go up way higher, often as high as 15mg, either because they respond differently to the medication or because they need more help to quiet the noise than others. Dosage is everything!
 
MindzEye said:
Why? Dopamine isn't the only hormone involved in hunger, satiety, etc. It's not even the dominant one. It's just the one that makes us make bad decisions more often.

Like, GLP-1 could have saved you from banging that...lovely lady, I'm sure....in the bathroom of a fast food restaurant back in the day. But it also would have probably stopped you from weighing your nuts and talking about it on the internet, so you know, not all good news.
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yeah thanks for proving how evil this shit is. no thanks.
 
Preston said:
If you take 20 tylenol for a mild headache, you don't get extra healed! It's the same with dopamine, you don't want more and more removal. You want the exact amount that helps support your disease/addiciton/mental illness. You need just enough reformatting to bring the food noise down to a level where you can actually make a choice about what to eat.

The starting dose is 2.5mg, it's known as the therapeutic dose because it generally doesn't work for many - roughly 10% respond to it; side effects are low and effectiveness is low. Those super responders that shed weight on that dose will often stay at 2.5mg. Others have to go up way higher, often as high as 15mg, either because they respond differently to the medication or because they need more help to quiet the noise than others. Dosage is everything!
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but i mean 0 dopamine reward for eating surely has to be best for weight loss?
 
yeah it would make you eat only for nourishment, not for pleasure.

just boiled potatoes all day long.
 
zeke said:
but i mean 0 dopamine reward for eating surely has to be best for weight loss?
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Well, no. Even ignoring the dopamine response aspect. Faster weight loss is not better weight loss. I mean, you touched on this yourself with the gaunt face question. Even hitting higher doses of the stuff now, without a bunch of other mitigation issues causes most people to lose weight so fast that yeah, their face looks all off for months after they hit their end weight.
 
if we only function due to dopamine rewards, sounds pretty fucking dangerous to start fucking with it.
 
MindzEye said:
Well, no. Even ignoring the dopamine response aspect. Faster weight loss is not better weight loss. I mean, you touched on this yourself with the gaunt face question. Even hitting higher doses of the stuff now, without a bunch of other mitigation issues causes most people to lose weight so fast that yeah, their face looks all off for months after they hit their end weight.
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but i mean faster weight loss is what most people want?
 
zeke said:
if we only function due to dopamine rewards, sounds pretty fucking dangerous to start fucking with it.
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This would be true if all humans baseline had a perfectly functional and balanced state. The reason these meds exist is that for many people, their system is already fucked with, whether it be by ultra processed foods or genetics. The medication is to treat their fucked system, not fuck their perfectly balanced system. If they had a perfect system they wouldn't take the drug.
 
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