I actually think we're going to see the opposite and we're going to see not how organized they are, but how decentralized they are and how that makes them far, far more resilient than organization does. The vast, vast majority of the drugs passes through border checkpoints and are smuggled by American citizens who live in border cities and cross regularly. Just at one border crossing between TJ & San Diego, Ysidro, 40K vehicles and over 100K people per today cross legally. That's the busiest crossing on the border, but that's one of 50 border crossings. Most of the fentanyl smuggled in (like, 90%+) is smuggled in small batches, carried across in day bags and backpacks by people legally allowed to cross the border.
Where this might have impact is in human trafficking (it's difficult for migrants to even reach the border region without being escorted in by the chain of coyotes). The human trafficking occurs in the empty spaces between border check points, is way easier to interdict with drones, sensors, cameras, etc. I could see that slow down signficantly (and other modes pick up some of the slack, like air travel, sea smuggling, etc). But what I think is fairly unlikely is the coyotes getting into fire fights. That's bad for business, they'll find ways to adapt instead.
As usual, it's the poorest people in the equation that will suffer the most. The migrants caught in between the coyote/cartel network and increased "enforcement".