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OT: Coronavirus Resources - and other things to not worry about

zeke said:
the irony is that drugs will most likely have much worse side effects than vaccines.
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Sometimes the vaccine ain't enough. This is a crucial tool for the elderly/vulnerable who have high fatality rates and are currently filling hospitals; the Pfizer product cut hospitalizations/deaths down by 89% in trials (only trialed in unvaxxed folks so TBD on how well it'll work on vaxxed). Won't likely ever be available for lower risk folks.
 
3448 hospitalized currently in Ontario. Around 70% are fully vaxxed, for reference.

If we include unvaxxed (fuck 'em, but whatever) and let's say we gave Paxlovid to half of the folks, we save around 1500-1600 hospitalizations if the data holds up in a real world situation; so we'd be down to under 2000 hospitalizations just like that. 505 in ICU? Give Paxlovid to half of 'em and we're looking at under 300. We're talking medium to longterm here before it's widely available but this is gonna be a big help and give us some more leeway.
 
Some popular medical chemist blogger dude who is a very bright fella with experience in the biotech field had an AMA. Some interesting tidbits from a dude with a different perspective than a virologist.

On Paxlovid.

Longterm outlook on use and combining them in cocktail-form to prevent resistance:
You always worry about resistance with small molecules, for sure. And I don’t see any reason why this virus should be any different. I think that drugs like Paxlovid are really for people with risk factors that might land them in the hospital, not for everyone to take at all times. That would bring on trouble even faster! So I think they can make a difference if used wisely - whether we use them that way or not is another question. . .
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Exactly. I think any long-term small molecule solution will have to be a cocktail of different mechanisms. There are a number of other protease inhibitors and other compounds working their way through development, fortunately. I had hoped that all that would turn out to be wasted effort, but no such luck!
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Paxlovid (the Pfizer drug) is in fact a protease inhibitor, and there are quite a few more in development! They will eventually (you'd think) need to be combined with other drugs with different mechanistic targets, just as with HIV therapy, though.
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On producing at scale:
The big risk is if we don't get enough of it made to make a difference. Pfizer is very, very good at scale-up and chemical manufacturing, so I believe that they're giving it as good a shot as anyone could give it.

The other thing is that we really need to make sure that it goes to high-risk patients, to keep them out of the hospital and out of the ICU. It's not a drug for everyone to take whenever they might feel some Covid coming on, if you know what I mean.

The influenza antivirals have never made much of an impact, but Hep C ones sure have. I think that long term a coronavirus small-molecule therapy will have to be a cocktail of more than one drug with more than one mechnism of action, though, like Hep C or HIV therapies.
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The problem with Paxlovid is supply of chemical reagents and intermediates, and most of those are coming from offshore producers. We can sit here in the US and talk about "national priority" and "Warp Speed" and "Defense Production Act" all we want, but these things are being made in India and China, and we simply don't have the capacity to produce the building blocks in the US at speed and at scale. . .
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On Omicron boosters
I think the vaccines can be modified pretty quickly, at least to the manufacturing part. What we don't know is how well they'll work across the existing variants (although maybe it's going to mostly Omicron for a while?)
A big problem is that there's only so much manufacturing capacity in the world, so if you switch, you can't do both. It's a very, very tough call, and frankly I think the existing vaccines are still wotking well enough not to switch yet
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On nasal vaccines
I really need to try to get a better perspective on those! It's always been a promising idea, but there's so much that we don't understand in detail, immunologically, about these different modes of administration that I think we're just going to have to brute-force our way through human trials and hope that something works. . .
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On pan-coronavirus vaccines (like the one mentioned earlier) and answering whether he thinks that immunity could be longer lasting with future vaccines:
I know that a lot of groups are wotking on this, and I think that's really valuable research. But these things have to be proven in human trials; there's no other way to be sure. As for longer-lasting immunity, we really don't understand enough about why different things wane at different rates! It's one of those topics that everyone wants to know more about, but immunology, sheesh. . .So I don't think we can design that in, unfortunately.
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I still can't believe how popular Rogan got. I remember him on Stern when he was nobody. The gang would rip him for verbally abusing women at strip clubs in Vegas and he got really defensive and angry that they would talk about it on the radio.
 
Moderna speaks:

Statement on COVID-19 Vaccine Clinical Studies in Children & Adolescents

The U.S. FDA requested additional participants at a given dose level in pediatric cohorts after the VRBPAC review of requirements for pediatric EUA on June 10, 2021, and Moderna complied at that time. Outside the United States, Moderna has received regulatory authorizations in Europe, UK...
investors.modernatx.com investors.modernatx.com

We expect to report data in children 2-5 years of age in March. If the data is supportive and subject to regulatory consultation, Moderna may proceed with regulatory filings for children 2-5 years of age thereafter.
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From my understanding (based on people I know and things I heard) they are hoping for an April or May approval. This is likely to be the first approval for this age group and before Pfizer.
 
In 2011 or 2012 I would listen to Rogan. He had a forum that was crazy. So many white supremacy supporters and conspiracy theorists. He shuttered the place once he started growing. Sounds like he is just returning to his roots.
 
So doctor PrestoFauci, or anyone else in the know. If my hubs just had Covid. Still feeling a headache but it’s been the five days as of tomorrow, when can he get boosted? He has his appt for Friday and is wondering if that’s not a great idea
 
blkngldbabe said:
So doctor PrestoFauci, or anyone else in the know. If my hubs just had Covid. Still feeling a headache but it’s been the five days as of tomorrow, when can he get boosted? He has his appt for Friday and is wondering if that’s not a great idea
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I don't know the answer, but I can tell you that on two separate occasions today before they gave me my booster they went through a list of symptoms to confirm that I did not have any. dunno what happens if you say yes to any of them, so this is probably not all that helpful but I will share anyways
 
blkngldbabe said:
So doctor PrestoFauci, or anyone else in the know. If my hubs just had Covid. Still feeling a headache but it’s been the five days as of tomorrow, when can he get boosted? He has his appt for Friday and is wondering if that’s not a great idea
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Idk but I did a quick search and found this

This is the 'best time' to get your booster shot after being infected with COVID-19

Ontario's top doctor says he believes there is a 'best time immunologically' to get a COVID-19 vaccine booster shot after an active infection.
www.google.com www.google.com

I think waiting at least a month is your best bet. Extends immunity a little longer too.
 
SundinsTooth said:
In 2011 or 2012 I would listen to Rogan. He had a forum that was crazy. So many white supremacy supporters and conspiracy theorists. He shuttered the place once he started growing. Sounds like he is just returning to his roots.
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For a little while in 2016-2018 when he was just doing the youtube thing, I would catch the JRE snippets pretty regularly and there were basically 2 types of shows

-Him and his meathead MMA buddies or comedians shooting the shit
-Very interesting people doing very interesting things to whom Joe just asked good questions to because he was a self admitted dummy who didn't know enough to form an opinion on the matter. Would occasionally ask a brilliant scientists if they had ever used DMT, a sensory deprivation tank, eat elk, etc. Charming Joe Rogan stuff.

Since then he has sadly stopped believing that he was actually a moron and developed his own, often completely rubbish, opinions. He started platforming regressive twats instead of truly interesting people and went (at least) soft maga. It was truly a hell of a heel turn.

The r/joerogan subreddit is a civil war between old fans who are pulling the pin in droves and new alt reich fans who are thrilled to have a "centrist" giving them a platform.
 
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