Then we were told … ‘You get the vaccine and you get back to normal.’ And we haven’t gotten back to normal. And it’s ridiculous at this point …
Did you have to kick anyone on your commute?I like how almost a million people died in her country and the only thing she could come up with that she stayed at home with her subscription to multiple streaming services and like, wiped down her groceries. Fack off.
Did you have to kick anyone on your commute?![]()
Other research teams including McCray’s are working on Covid sprays — as well as some in Russia and India — but in the West, the Yale scientists are showing some of the best early results. Their new spray can “elicit mucosal immune memory within the respiratory tract,” they wrote.
There’s a problem, however. It could take a long time to fully develop a mucus-only vaccine for Covid. It would have to go through large-scale human trials over a period of many months — years, even — before the developers could approach health regulators for emergency approval.
To speed things along, Iwasaki, Golman-Israelow and the other Yale scientists are developing the spray vaccine strictly as a booster for the existing mRNA vaccines.
The Yale team is, in a sense, partially piggybacking on a vaccine that the U.S. Food and Drug Administration has already authorized for widespread use. “There might be a lower bar to getting into human studies if they’re working with something that’s already approved,” Palmer said.
The idea is to get your first two prime doses of mRNA as injections, then follow up later with a spray booster. The Yale scientists call it the “Prime and Spike” approach.
That’s a reference to the initial “prime” injections that are the first part of a full course of vaccine, and the spike protein that the novel coronavirus uses to grab onto and infect our cells. A fragment of that spike is the key ingredient in the experimental spray.
“We show that Prime and Spike induces robust T-resident memory cells, B-resident memory cells and [immunoglobulin A] at the respiratory mucosa, boosts systemic immunity and completely protects mice with partial immunity from lethal SARS-CoV-2 infection,” Iwasaki, Golman-Israelow and their colleagues wrote.
And since it’s so easy to use, it’s theoretically possible to develop a booster spray people can take at home. That “may make distribution easier,” Golman-Israelow says. And besides, any logistical hassle might be worth it if the spray booster offers better and more lasting protection — and is less scary, to boot.
The next step for the Yale team is to wrap up animal trials then test Prime and Spike on people and, if it still works and proves it’s safe, team up with a manufacturer to produce it–and ask regulators to greenlight it.
That could take months under the best of circumstances. But with the COVID pandemic entering its third year, a new booster that deploys months from now — or even in 2023 — is still pretty useful.
No! Fortunately I arrived to work with nary a soul in sight but the very distinctive smell of police horses still lingering in the air. Perhaps the people with lots of time on their hands went to Ottawa and everyone with jobs protested in Toronto.
Another account
so, a while back I noticed a significant turn in my dad's thinking about covid and lockdowns. he basically went from supporting them to being vehemently opposed.yeah, i get it, we're all tired. but none of those things she mentioned are any more than mild inconveniences. if that's what she's complaining about she had it pretty good.
she just sounds like a child.
lol at "damaging" restrictions