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OT: Coronavirus Resources - and other things to not worry about

It'll definitely be a process and it's not gonna get perfect overnight... And hell we may never get back to pre pandemic normalcy. But navigating the waves, pulling back when there's high transmission, taking advantage post-infection and boosting to extend immunity may become a way of life.

In the meantime vaccines will improve, treatments will improve and accumulated immunity will result in less severe outcomes as time goes on. Eventually it'll just become life.
 
Sublineage of omi likely outcompeting the original. A surprising number of mutations in this one, but based on Jesse Bloom's model our vaccines may work better on this one than the prior. Nothing crazy but just a bit better. Severity still TBD.



Same thing was happening with delta, where a sublineage was slowly taking over. And then omicron came and fucked it off. Same may happen again, but worth watching regardless. May be very minimal change. Omi infection + vaccine will cover this sublineage very well as per Mr. Bloom.
 
And early anecdotal info is that there's no significant change in clinical picture for this one. It's dominant in India currently.

m.timesofindia.com

BA.2 'stealth' variant makes up 80% of Kolkata's Omicron infections - Times of India

Nearly 80% of Covid-positive samples sent for genome-sequencing by laboratories in the city have been found to contain the BA.2 sub-lineage of the Omicron variant, nicknamed the 'stealth version', as it cannot be picked up in RT-PCR tests and requires genome-sequencing.
m.timesofindia.com m.timesofindia.com

Ignore the title "stealth variant" in the headline obviously. Just overly dramatic wording. The media is really dumb.
 
Interesting study

"We compared “recently injected” patients - that proved PCR-positive on the same day or on one of the five consecutive days after first vaccination (representing an unintended post-exposure-prophylaxis), to unvaccinated control group"







Tldr: it's not too late beleafer! Join us! Grass fed meat isn't a cure!
 
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Loads of debate about the role of t-cells in protection. But if they are major contributors to less severe illness this is very very very good news. Will be interesting to see data on 3 dose breakthrough severity vs 2 dose.




Caveat: tiny tiny sample size here. These preprints are all very imperfect even if they provide nice clues sometimes.
 
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